Joaquín Araos Henríquez, PhD
Tagline:Postdoctoral Research Associate | Cancer Research | Tumour microenvironment | Ageing
About Me
I studied biochemistry at the Pontificia Universidad Católica de Chile. After completing my undergraduate degree, I was awarded an Erasmus Mundus Joint master’s degree scholarship to study at the International Master in Innovative Medicine (IMIM) programme. As part of the IMIM programme, I carried out a research project at Katja Breitkopf-Heinlein laboratory (Heidelberg University) focusing on the role of the BMP-9 signalling pathway on the epithelial-to-mesenchymal transition of hepatocellular carcinoma cells. Later, I joined the laboratory of Theresa Vincent (Uppsala University) for a research project where I investigated the role of ribosome biogenesis on proneural-to-mesenchymal transition of glioblastoma cells.
I was awarded the Harding Distinguished Postgraduate scholarship to pursue my doctoral studies at the Cancer Research UK Cambridge Institute under the supervision of Dr Giulia Biffi. My doctoral project focused on characterising the impact of ageing on the malignant-to-stromal crosstalk in pancreatic ductal adenocarcinoma.
I am currently a Postdoctoral Research Associate in the laboratory of Daniel Muñoz-Espín in the Early Cancer Institute (Department of Oncology, University of Cambridge). I aim to dissect the molecular mechanisms by which ageing impacts lung cancer and how this shapes tumour initiation and progression. I have a particular interest in understanding the role of senescent cells within the human lung cancer microenvironment. My goal is to identify strategies to pharmacologically eliminate senescent cells and fight age-related diseases of the lung.
Outside of the lab, I enjoy playing and listening to music, photography and trying new cooking recipes.
Education
PhD in Medical Science
from: 2020, until: 2024Field of study:Cancer ResearchSchool:Queens' college, University of CambridgeLocation:Cambridge, United Kingdom
DescriptionSupervised by Dr Giulia Biffi (CRUK Cambridge Institute)
Funded by the Harding Distinguished Postgraduate Scholars Programme
Master of Science
from: 2018, until: 2019Field of study:Medical ScienceSchool:Uppsala UniversityLocation:Uppsala, Sweden
DescriptionStudies carried under the ERAMUS+ International Master in Innovative Medicine programme
Master of Science
from: 2017, until: 2018Field of study:Translational Medical ResearchSchool:Heidelberg UniversityLocation:Mannheim, Germany
DescriptionStudies carried under the ERAMUS+ International Master in Innovative Medicine programme
Bachelor of Science
from: 2012, until: 2017Field of study:BiochemistrySchool:Pontificia Universidad Católica de ChileLocation:Santiago, Chile
Research Interests
- Molecular and Cell Biology
- Cancer Research
- Tumour microenvironment
- Ageing
- Senescence
Publications
SMAD4 and KRAS status shape malignant-stromal crosstalk in pancreatic cancer
Journal ArticlePublisher:Cancer ResearchDate:2025Authors:Description:Previously published as preprint on bioRxiv: https://doi.org/10.1101/2022.12.05.519080
Modelling pancreatic cancer: from patients to pre-clinical models and back
Journal ArticlePublisher:Disease Models & MechanismsDate:2024Authors:EGFR-activated myofibroblasts promote metastasis of pancreatic cancer
Journal ArticlePublisher:Cancer CellDate:2024Authors:Description:Previously published as preprint on bioRxiv: https://doi.org/10.1101/2022.12.05.519080
Cancer Discovery’s research watch:
https://doi.org/10.1158/2159-8290.CD-RW2024-004
Scribble loss promotes pancreatic ductal adenocarcinoma development through cancer cell-intrinsic and extrinsic mechanisms
Journal ArticlePublisher:Cancer ResearchDate:2024Authors:Tissue-resident regulatory T cells exert dualistic anti-tumour and pro-repair function in the exocrine pancreas
Journal ArticlePublisher:bioRxivDate:2024Authors:Description:Preprint
Protocol for the characterization of the pancreatic tumor microenvironment using organoid-derived mouse models and single-nuclei RNA sequencing
Journal ArticlePublisher: STAR ProtocolsDate:2024Authors:Tracing back to one of the origins of immune evasion in pancreatic cancer
Journal ArticlePublisher:Cancer CellDate:2022Authors:Description:Preview to Huang et al., 2022 (10.1016/j.ccell.2022.04.011)
Down-regulation of SPARC is associated with EMT and low differentiation state of biliary tract cancer cells
Journal ArticlePublisher:European Surgical ResearchDate:2019Authors:The Role of Hypoxic Signalling in Metastasis: Towards Translating Knowledge of Basic Biology into Novel Anti-Tumour Strategies
Journal ArticlePublisher: Clinical & Experimental MetastasisDate:2018Authors:Sodium/proton exchanger isoform 1 regulates intracellular pH and cell proliferation in human ovarian cancer
Journal ArticlePublisher:Biochimica et Biophysica Acta (BBA) - Molecular Basis of DiseaseDate:2017Authors:Intracellular acidification increases adenosine transport in human umbilical vein endothelial cells
Journal ArticlePublisher:PlacentaDate:2017Authors:Insulin/adenosine axis linked signalling
Journal ArticlePublisher:Molecular Aspects of MedicineDate:2017Authors:Akt/mTOR decreased signalling in human foetoplacental vascular insulin resistance in pregestational maternal obesity, preeclampsia, and gestational diabetes mellitus
Journal ArticlePublisher:Journal of Diabetes ResearchDate:2017Authors:Intracellular and extracellular pH dynamics in the human placenta from diabetes mellitus
Journal ArticlePublisher:PlacentaDate:2016Authors:Insulin Is a Key Modulator of Fetoplacental Endothelium Metabolic Disturbances in Gestational Diabetes Mellitus
Journal ArticlePublisher:Frontiers in PhysiologyDate:2016Authors:Nitric oxide and pH modulation in gynaecological cancer
Journal ArticlePublisher:Journal of Cellular and Molecular MedicineDate:2016Authors:Modulation of intracellular pH in human ovarian cancer
Journal ArticlePublisher:Current Molecular MedicineDate:2016Authors:Are NHE1 and inducible nitric oxide synthase involved in human ovarian cancer?
Journal ArticlePublisher:Pharmacological ResearchDate:2016Authors:Escherichia coli Heat-Stable Enterotoxin Mediates Na+/H+ Exchanger 4 Inhibition Involving cAMP in T84 Human Intestinal Epithelial Cells
Journal ArticlePublisher:PLoS OneDate:2015Authors:
Contact
Address
jaraoshenriquez@gmail.com
jea70@cam.ac.uk