Joaquín Araos Henríquez, PhD

Tagline:Postdoctoral Research Associate | Cancer Research | Tumour microenvironment | Ageing

personal photo of Joaquín Araos Henríquez, PhD

About Me

I studied biochemistry at the Pontificia Universidad Católica de Chile. After completing my undergraduate degree, I was awarded an Erasmus Mundus Joint master’s degree scholarship to study at the International Master in Innovative Medicine (IMIM) programme. As part of the IMIM programme, I carried out a research project at Katja Breitkopf-Heinlein laboratory (Heidelberg University) focusing on the role of the BMP-9 signalling pathway on the epithelial-to-mesenchymal transition of hepatocellular carcinoma cells. Later, I joined the laboratory of Theresa Vincent (Uppsala University) for a research project where I investigated the role of ribosome biogenesis on proneural-to-mesenchymal transition of glioblastoma cells.

I was awarded the Harding Distinguished Postgraduate scholarship to pursue my doctoral studies at the Cancer Research UK Cambridge Institute under the supervision of Dr Giulia Biffi. My doctoral project focused on characterising the impact of ageing on the malignant-to-stromal crosstalk in pancreatic ductal adenocarcinoma.

I am currently a Postdoctoral Research Associate in the laboratory of Daniel Muñoz-Espín in the Early Cancer Institute (Department of Oncology, University of Cambridge). I aim to dissect the molecular mechanisms by which ageing impacts lung cancer and how this shapes tumour initiation and progression. I have a particular interest in understanding the role of senescent cells within the human lung cancer microenvironment. My goal is to identify strategies to pharmacologically eliminate senescent cells and fight age-related diseases of the lung.

Outside of the lab, I enjoy playing and listening to music, photography and trying new cooking recipes.

Education

  • PhD in Medical Science

    from: 2020, until: 2024

    Field of study:Cancer ResearchSchool:Queens' college, University of CambridgeLocation:Cambridge, United Kingdom

    Description

    Supervised by Dr Giulia Biffi (CRUK Cambridge Institute)

    Funded by the Harding Distinguished Postgraduate Scholars Programme

  • Master of Science

    from: 2018, until: 2019

    Field of study:Medical ScienceSchool:Uppsala UniversityLocation:Uppsala, Sweden

    Description

    Studies carried under the ERAMUS+ International Master in Innovative Medicine programme

  • Master of Science

    from: 2017, until: 2018

    Field of study:Translational Medical ResearchSchool:Heidelberg UniversityLocation:Mannheim, Germany

    Description

    Studies carried under the ERAMUS+ International Master in Innovative Medicine programme

  • Bachelor of Science

    from: 2012, until: 2017

    Field of study:BiochemistrySchool:Pontificia Universidad Católica de ChileLocation:Santiago, Chile

Research Interests

  • Molecular and Cell Biology
  • Cancer Research
  • Tumour microenvironment
  • Ageing
  • Senescence

Publications

  • SMAD4 and KRAS status shape malignant-stromal crosstalk in pancreatic cancer

    Journal ArticlePublisher:Cancer ResearchDate:2025
    Authors:
    Description:

    Previously published as preprint on bioRxiv: https://doi.org/10.1101/2022.12.05.519080

  • Modelling pancreatic cancer: from patients to pre-clinical models and back

    Journal ArticlePublisher:Disease Models & MechanismsDate:2024
    Authors:
  • EGFR-activated myofibroblasts promote metastasis of pancreatic cancer

    Journal ArticlePublisher:Cancer CellDate:2024
    Authors:
    Description:

    Previously published as preprint on bioRxiv: https://doi.org/10.1101/2022.12.05.519080

    Cancer Discovery’s research watch:

    https://doi.org/10.1158/2159-8290.CD-RW2024-004

  • Scribble loss promotes pancreatic ductal adenocarcinoma development through cancer cell-intrinsic and extrinsic mechanisms

    Journal ArticlePublisher:Cancer ResearchDate:2024
    Authors:
  • Tissue-resident regulatory T cells exert dualistic anti-tumour and pro-repair function in the exocrine pancreas

    Journal ArticlePublisher:bioRxivDate:2024
    Authors:
    Description:

    Preprint

  • Protocol for the characterization of the pancreatic tumor microenvironment using organoid-derived mouse models and single-nuclei RNA sequencing

    Journal ArticlePublisher: STAR ProtocolsDate:2024
    Authors:
  • Tracing back to one of the origins of immune evasion in pancreatic cancer

    Journal ArticlePublisher:Cancer CellDate:2022
    Authors:
    Description:

    Preview to Huang et al., 2022 (10.1016/j.ccell.2022.04.011)

  • Down-regulation of SPARC is associated with EMT and low differentiation state of biliary tract cancer cells

    Journal ArticlePublisher:European Surgical ResearchDate:2019
    Authors:
  • The Role of Hypoxic Signalling in Metastasis: Towards Translating Knowledge of Basic Biology into Novel Anti-Tumour Strategies

    Journal ArticlePublisher: Clinical & Experimental MetastasisDate:2018
    Authors:
  • Sodium/proton exchanger isoform 1 regulates intracellular pH and cell proliferation in human ovarian cancer

    Journal ArticlePublisher:Biochimica et Biophysica Acta (BBA) - Molecular Basis of DiseaseDate:2017
    Authors:
  • Intracellular acidification increases adenosine transport in human umbilical vein endothelial cells

    Journal ArticlePublisher:PlacentaDate:2017
    Authors:
  • Insulin/adenosine axis linked signalling

    Journal ArticlePublisher:Molecular Aspects of MedicineDate:2017
    Authors:
  • Akt/mTOR decreased signalling in human foetoplacental vascular insulin resistance in pregestational maternal obesity, preeclampsia, and gestational diabetes mellitus

    Journal ArticlePublisher:Journal of Diabetes ResearchDate:2017
    Authors:
  • Intracellular and extracellular pH dynamics in the human placenta from diabetes mellitus

    Journal ArticlePublisher:PlacentaDate:2016
    Authors:
  • Insulin Is a Key Modulator of Fetoplacental Endothelium Metabolic Disturbances in Gestational Diabetes Mellitus

    Journal ArticlePublisher:Frontiers in PhysiologyDate:2016
    Authors:
  • Nitric oxide and pH modulation in gynaecological cancer

    Journal ArticlePublisher:Journal of Cellular and Molecular MedicineDate:2016
    Authors:
  • Modulation of intracellular pH in human ovarian cancer

    Journal ArticlePublisher:Current Molecular MedicineDate:2016
    Authors:
  • Are NHE1 and inducible nitric oxide synthase involved in human ovarian cancer?

    Journal ArticlePublisher:Pharmacological ResearchDate:2016
    Authors:
  • Escherichia coli Heat-Stable Enterotoxin Mediates Na+/H+ Exchanger 4 Inhibition Involving cAMP in T84 Human Intestinal Epithelial Cells

    Journal ArticlePublisher:PLoS OneDate:2015
    Authors:
© 2025 Joaquín Araos Henríquez, PhD